Ribonucleotides are frequently misincorporated into DNA during replication, arising from imperfect sugar discrimination by DNA polymerases and high intracellular ribonucleotide triphosphate pools.
DNA replication in eukaryotes is a highly orchestrated process that ensures precise genome duplication before cell division. Initiation occurs at multiple replication origins that are licensed in G1 ...
An international collaboration steered by David Cortez, Richard N. Armstrong, Ph.D. Chair for Innovation in Biochemistry, explored how cells tolerate DNA damage and genome instability—and they arrived ...
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